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发热伴血小板减少综合征病毒（Severe fever with thrombocytopenia syndrome virus,SFTSV）主要经蜱叮咬传播，累及范围呈不断扩大趋势，其流行具有明显的时空聚集性。近年来，SFTSV分子流行病学和基于病毒基因组序列的系统发育研究其起源、遗传进化、基因多样性与传播等方面的重要进展，为进一步理解该病毒流行趋势和动态特征提供了有益的佐证。本文围绕SFTSV分子流行病学和遗传进化特征研究，系统综述了SFTSV的生物学与流行病学基础、进化速率、遗传进化以及起源与地理扩散特征，概述了病毒遗传差异与临床结局之间的研究进展。
Abstract：Severe fever with thrombocytopenia syndrome virus(SFTSV) is a tick-borne pathogen with an expanding geographic distribution and marked spatiotemporal clustering. In recent years, advances in molecular epidemiology and phylogenetic analyses based on viral genome sequences have provided important insights into the origin, genetic evolution, diversity, and transmission dynamics of SFTSV, contributing to a better understanding of its epidemiological trends and patterns. This review focuses on recent progress in studies of the molecular epidemiology and evolutionary characteristics of SFTSV. It systematically summarizes the biological and epidemiological features of the virus and highlights current knowledge on evolutionary rates, genetic diversification, and patterns of origin and geographic spread. In addition, recent advances in understanding the associations between viral genetic variation and clinical outcomes are discussed. Overall, integrating molecular epidemiological and evolutionary approaches into surveillance systems may enhance the understanding of transmission dynamics and risk characteristics of SFTSV and provide a scientific basis for more precise prevention and control strategies.
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基本信息:
中图分类号:R512.8
引用信息:
[1]郑岚菱,田芳桢,顾天梦,等.发热伴血小板减少综合征病毒分子流行病学与遗传进化特征研究进展[J].病毒学报().
基金信息:
首都卫生发展科研专项重点攻关项目（项目号：2026-1G-3011）,题目：北京市发热伴血小板减少综合征传播特征及流行风险研究
2026-06-01
2026-06-01
2026-06-01