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慢性乙型肝炎(CHB)是严重公共卫生问题,其疾病进展受病毒、宿主及免疫等多重因素影响。现有核苷(酸)类似物(NAs)和聚乙二醇干扰素(Peg-IFN)虽可抑制病毒复制,但功能性治愈率低。近年来新型药物不断涌现,为提升治愈率带来希望。本文系统梳理CHB发病与进展的风险因素,综述传统及新型抗病毒药物的临床应用进展,为临床防治提供参考。
Abstract:Chronic hepatitis B(CHB) remains a major global public health concern, and its onset and progression are influenced by multiple factors, including viral, host, and immune determinants. Currently available antiviral therapies, including nucleos(t)ide analogues(NAs) and pegylated interferon(Peg-IFN), can effectively suppress viral replication; however, the rate of functional cure remains low. In recent years, the emergence of novel therapeutic agents has provided new opportunities to improve treatment outcomes. This review systematically summarizes the risk factors associated with the development and progression of CHB and discusses recent advances in the clinical application of both conventional and emerging antiviral therapies, with the aim of providing references for clinical prevention and treatment strategies.
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基本信息:
中图分类号:R512.62
引用信息:
[1]刘慧敏,朴红心,王童舒,等.慢性乙型肝炎患者发病和疾病进展相关因素及其抗病毒药物治疗的临床应用进展[J].病毒学报().
基金信息:
吉林省科技发展计划项目(项目号:YDZJ202201ZYTS233),题目:ALKBH5-m6A-FOXM1信号轴对小鼠肝纤维化模型的调控研究; 国家自然科学基金(项目号:82260506),题目:FUBP3调控FOXM1的可变剪接促进肝癌细胞增殖与转移机制的研究
2026-04-07
2026-04-07
2026-04-07