nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg journalInfo journalinfonormal searchdiv searchzone qikanlogo popupnotification paper paperNew
2026, 02, v.30 87-95+157
毛皮动物育种技术研究进展
基金项目(Foundation): 中国农业科学院科技创新工程项目(CAAS-ASTIP-ISAPS-2025)
邮箱(Email): liuzongyue@caas.cn;
DOI: 10.13326/j.jea.2026.2091
发布时间: 2025-05-20
出版时间: 2025-05-20
网络发布时间: 2025-05-20
移动端阅读
摘要:

开展遗传育种研究是毛皮动物养殖业可持续发展的关键。从孟德尔遗传定律和群体遗传学的兴起,到数量遗传学和分子生物学的持续进步,毛皮动物育种逐渐进入“后基因组时代”。在此期间,常规育种、分子标记辅助选择以及基因组选择等技术广泛应用,推动毛皮动物育种技术的发展。目前尚缺乏对毛皮动物育种成果和研究进展的系统梳理,无法为毛皮动物养殖业提供可借鉴的育种发展路径。文章介绍国内外毛皮动物品种培育状况和产业现状,详细阐述了常规育种、分子标记辅助选择和基因组选择在毛皮动物生产以及性状改良领域的相关研究进展,以期为毛皮动物育种研究以及实际生产提供参考。

Abstract:

Genetic breeding research is a key to the sustainable development of the fur-bearing animal breeding industry. From the emergence of Mendelian genetics and population genetics to the continuous advancement of quantitative genetics and molecular biology, the breeding of fur-bearing animals has progressively entered the post-genomic era. During this period, technologies such as conventional breeding, molecular marker-assisted selection, and genomic selection have been widely applied, promoting the development of fur-bearing animal breeding. To date, there is a lack of systematic reviews summarizing the breeding achievements and research advancements in fur-bearing animals, making it difficult to establish a referenceable breeding development pathway for the industry. This paper introduces the current status of the fur-bearing animal industry and the situation of breed cultivation at home and abroad, and elaborates on the relevant research progress of conventional breeding, molecular marker-assisted selection, and genomic selection technology in the production and performance improvement of fur-bearing animals, aiming to provide references for the breeding research and practical production of fur-bearing animals.

参考文献

[1]姜春生,吴维芳.吉林白水貂的特征及饲养技术[J].毛皮动物饲养,1982(4):24-26, 28.

[2]国家畜禽遗传资源委员会办公室.关于公布《国家畜禽遗传资源品种名录》的通知[EB/OL].(2023-02-27)[2024-12-25]. http://www--gov.cn/zhengce/zhengceku/2023-02/27/content_5743543.htm.

[3]王殿华,李霞. 2020年中国水貂、狐、貉取皮数量统计及市场分析[J].北京皮革,2021, 46(4):62-64.

[4]刘继强,郝晓东,武丽娜,等.全基因组SNP分型技术在畜禽遗传育种研究中的应用[J].畜牧兽医学报,2022, 53(12):4123-4137.

[5]刘宗岳,李虎,邵西群,等.水貂健康养殖与动物福利研究进展[J].经济动物学报,2025, 29(4):277-282.

[6]张志明.从中国与丹麦、美国水貂养殖现状比较看中国水貂产业化发展方向[J].特种经济动植物,2005, 8(9):2-5.

[7]刘宗岳. 2021年毛皮动物产业形势分析与2022年展望[J].畜牧产业,2022(4):32-36.

[8]谭书岩,谭树良,张爱东,等.芬兰原种北极狐改良提高地产狐的效果评定[J].经济动物学报,2007, 11(2):80-82.

[9]鲍加荣,刘伟,刘玲琳,等.赤狐的选种与选配[C]//中国毛皮动物科学研究进展——2014年全国毛皮动物专业学术研讨会论文集.青岛:[出版社不详],2014:263-267.

[10]刘秀英.芬兰蓝狐改良本地蓝狐的生产性能研究[J].畜牧兽医科技信息,2013(11):100.

[11]郭跃跃,张宇飞,王天骄,等.黑貉TYRP1基因的克隆及生物信息学分析[J].中国畜牧兽医,2019, 46(5):1299-1307.

[12]宋兴超,刘琳玲,潘虹军,等.水貂酪氨酸酶(TYR)基因克隆、SNPs筛查及其皮肤组织mRNA差异表达分析[J].畜牧兽医学报,2021, 52(1):66-76.

[13]张胜利,杨秀文,靳明武,等.遗传参数不同估计方法的比较[J].遗传,1995, 17(6):21-23.

[14]邓丽琴,祝朋芳,陈长青.试论常规育种与分子育种的研究应用[J].杂粮作物,2004, 24(5):280-281.

[15]Liu Z Y, Liu L L, Song X C, et al. Heritability and genetic trends for growth and fur quality traits in silver blue mink[J].Italian Journal of Animal Science, 2017, 16(1):39-43.

[16]Thirstrup J P, Jensen J, Lund M S. Genetic parameters for fur quality graded on live animals and dried pelts of American mink(Neovison vison)[J]. Journal of Animal Breeding and Genetics, 2017, 134(4):322-331.

[17]Karimi K, Sargolzaei M, Plastow G S, et al. Genetic and phenotypic parameters for litter size, survival rate, gestation length, and litter weight traits in American mink[J]. Journal of Animal Science, 2018, 96(7):2596-2606.

[18]Valipour S, Karimi K, Barrett D, et al. Genetic and phenotypic parameters for pelt quality and body length and weight traits in American mink[J]. Animals, 2022, 12(22):3184.

[19]Kempe R, Koskinen N, Strandén I. Genetic parameters of pelt character, feed efficiency and size traits in Finnish blue fox(Vulpes lagopus)[J]. Journal of Animal Breeding and Genetics, 2013, 130(6):445-455.

[20]张敏,白秀娟,杜智恒.大兴安岭地区北极狐生产性能的相关研究[J].安徽农业科学,2009, 37(21):10002-10003,10007.

[21]Kempe R, Strandén I. Breeding for better eye health in Finnish blue fox(Vulpes lagopus)[J]. Journal of Animal Breeding and Genetics, 2016, 133(1):51-58.

[22]Kempe R, Koskinen N, Mäntysaari E, et al. The genetics of body condition and leg weakness in the blue fox(Alopex lagopus)[J]. Acta Agriculturae Scandinavica, Section A-Animal Science, 2010, 60(3):141-150.

[23]张志明,涂剑锋,胡大伟,等.明华黑色水貂培育研究报告[J].经济动物学报,2017, 21(3):125-127.

[24]涂剑锋,荣敏,张志明,等.名威银蓝水貂培育简报[J].特产研究,2019, 41(2):50-53.

[25]Lagerkvist G, Johansson K, Lundeheim N. Selection for litter size, body weight, and pelt quality in mink(Mustela vison):Correlated responses[J]. Journal of Animal Science, 1994,72(5):1126-1137.

[26]Koivula M, Strandén I, Mäntysaari E A. Direct and maternal genetic effects on first litter size, maturation age, and animal size in Finnish minks[J]. Journal of Animal Science, 2009,87(10):3083-3088.

[27]Wierzbicki H. Breeding value evaluation in Polish fur animals:Estimates of direct heritability and portion of litter variation of fur coat and reproduction traits[J]. Czech Journal of Animal Science, 2004, 49(11):474-482.

[28]Skakkebæk N E, Lindahl-Jacobsen R, Levine H, et al. Environmental factors in declining human fertility[J]. Nature Reviews Endocrinology, 2022, 18(3):139-157.

[29]Koivula M, Mäntysaari E A, Strandén I. New fertility traits in breeding value evaluation of Finnish blue fox[J]. Acta Agriculturae Scandinavica, Section A-Animal Science, 2009,59(3):131-136.

[30]杨运清,缪尧源.动物生长曲线拟合方法的探讨[J].畜牧兽医学报,1992, 23(3):219-224.

[31]荣敏,涂剑锋,徐佳萍,等. 3种水貂资源群体生长曲线的拟合和比较[J].畜牧与兽医,2017, 49(10):13-16.

[32]荣敏,涂剑锋,徐佳萍,等.不同彩貂生长发育比较及生长曲线拟合研究[J].黑龙江畜牧兽医,2018(9):184-186, 251.

[33]Bai X, Liu Z, Ning F, et al. Modelling growth of five different colour types of mink[J]. South African Journal of Animal Science, 2011, 41(2):116-125.

[34]Do D N, Miar Y. Evaluation of growth curve models for body weight in American mink[J]. Animals, 2020, 10(1):22.

[35]Lecis R, Ferrando A, Ruiz-Olmo J, et al. Population genetic structure and distribution of introduced American mink(Mustela vison)in Spain, based on microsatellite variation[J]. Conservation Genetics, 2008, 9(5):1149-1161.

[36]Mora M, Medina-Vogel G, Sepúlveda M A, et al. Genetic structure of introduced American mink(Neovison vison)in Patagonia:Colonisation insights and implications for control and management strategies[J]. Wildlife Research, 2018,45(4):344.

[37]Michalska-Parda A, BrzeziÑski M, Zalewski A, et al. Genetic variability of feral and ranch American mink Neovison vison in Poland[J]. Mammal Research, 2009, 54(1):1-10.

[38]Hammershøj M, Pertoldi C, Asferg T, et al. Danish freeranging mink populations consist mainly of farm animals:Evidence from microsatellite and stable isotope analyses[J].Journal for Nature Conservation, 2005, 13(4):267-274.

[39]Zalewski A, Zalewska H, Lunneryd S G, et al. Reduced genetic diversity and increased structure in American mink on the Swedish coast following invasive species control[J]. PLoS One, 2016, 11(6):e0157972.

[40]Zhang L N, Hua Y, Wei S C. High genetic diversity of an invasive alien species:Comparison between fur-farmed and feral American mink(Neovison vison)in China[J]. Animals,2021, 11(2):472.

[41]王红梅.水貂产仔性状相关基因及遗传多样性研究[D].哈尔滨:东北农业大学,2007.

[42]杨洪雁.水貂PIT-1基因多态性及遗传多样性的研究[D].哈尔滨:东北农业大学,2010.

[43]Kukekova A V, Trut L N, Oskina I N, et al. A marker set for construction of a genetic map of the silver fox(Vulpes vulpes)[J]. The Journal of Heredity, 2004, 95(3):185-194.

[44]Hong Y, Lee H, Kim K S, et al. Phylogenetic relationships between different raccoon dog(Nyctereutes procyonoides)populations based on four nuclear and Y genes[J]. Genes&Genomics, 2020, 42(9):1075-1085.

[45]GriciuvienėL, Paulauskas A, Radzijevskaja J, et al. Impact of anthropogenic pressure on the formation of population structure and genetic diversity of raccoon dog Nyctereutes procyonoides[J]. Current Zoology, 2016, 62(5):413-420.

[46]Jee H, Seok K, Min M S, et al. Population structure of the raccoon dog(Nyctereutes procyonoides)using microsatellite loci analysis in South Korea:Implications for disease management[J]. The Journal of Veterinary Medical Science,2018, 80(10):1631-1638.

[47]苏成付.分子标记辅助选择育种发展策略[J].安徽农业科学,2014, 42(15):4591-4592, 4598.

[48]Anistoroaei R, Menzorov A, Serov O, et al. The first linkage map of the American mink(Mustela vison)[J]. Animal Genetics, 2007, 38(4):384-388.

[49]Szczerbal I, Rogalska-Niznik N, Schelling C, et al. Development of a cytogenetic map for the Chinese raccoon dog(Nyctereutes procyonoides Procyonoides)and the Arctic fox(Alopex lagopus)genomes, using canine-derived microsatellite probes[J].Cytogenetic and Genome Research, 2003, 102(1/2/3/4):267-271.

[50]Zatoń-Dobrowolska M, Mucha A, Wierzbicki H, et al. Microsatellite polymorphism and its association with body weight and selected morphometrics of farm red fox(Vulpes vulpes L.)[J].Journal of Applied Genetics, 2014, 55(4):475-484.

[51]Valipour S, Karimi K, Do D N, et al. Genome-wide detection of selection signatures for pelt quality traits and coat color using whole-genome sequencing data in American mink[J].Genes, 2022, 13(11):1939.

[52]Anistoroaei R, Fredholm M, Christensen K, et al. Albinism in the American mink(Neovison vison)is associated with a tyrosinase nonsense mutation[J]. Animal Genetics, 2008,39(6):645-648.

[53]宋兴超,徐超,刘宗岳,等.水貂TYR基因T138A位点多态性及其与毛色性状的关联分析[J].中国畜牧兽医,2017,44(10):2973-2979.

[54]Blaszczyk W M, Distler C, Dekomien G, et al. Identification of a tyrosinase(TYR)exon 4 deletion in albino ferrets(Mustela putorius Furo)[J]. Animal Genetics, 2007, 38(4):421-423.

[55]邢思远.水貂TYR基因单核苷酸多态性与毛色的相关研究[D].北京:中国农业科学院,2014.

[56]Cirera S, Markakis M N, Kristiansen T, et al. A large insertion in intron 2 of the TYRP1 gene associated with American Palomino phenotype in American mink[J]. Mammalian Genome, 2016, 27(3):135-143.

[57]Markakis M N, Soedring V E, Dantzer V, et al. Association of MITF gene with hearing and pigmentation phenotype in Hedlund white American mink(Neovison vison)[J]. Journal of Genetics, 2014, 93(2):477-481.

[58]宋兴超,徐超,刘宗岳,等.美洲水貂刺鼠信号蛋白基因SNPs检测及其与毛色表型的关联分析[J].畜牧兽医学报,2016, 47(4):723-732.

[59]Cirera S, Markakis M N, Christensen K, et al. New insights into the melanophilin(MLPH)gene controlling coat color phenotypes in American mink[J]. Gene, 2013, 527(1):48-54.

[60]Anistoroaei R, Krogh A K, Christensen K. A frameshift mutation in the LYST gene is responsible for the Aleutian color and the associated Chédiak-Higashi syndrome in American mink[J]. Animal Genetics, 2013, 44(2):178-183.

[61]Cadieu E, Neff M W, Quignon P, et al. Coat variation in the domestic dog is governed by variants in three genes[J]. Science, 2009, 326(5949):150-153.

[62]Thirstrup J P, Anistoroaei R, Guldbrandtsen B, et al. Identifying QTL and genetic correlations between fur quality traits in mink(Neovison vison)[J]. Animal Genetics, 2014, 45(1):105-110.

[63]刘琳玲,宋兴超,丛波,等.水貂FGF5基因多态性及其与毛长性状的关联分析[J].特产研究,2020, 42(5):45-49.

[64]梁东. FGF5基因对水貂毛长性状的影响研究[D].北京:中国农业科学院,2011.

[65]Våge D I, Fuglei E, Snipstad K, et al. Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox(Alopex lagopus)and prevent expression of the white winter coat[J]. Peptides, 2005, 26(10):1814-1817.

[66]洪支林.北极白狐毛色季节性变化候选基因WNT5A的功能验证[D].秦皇岛:河北科技师范学院,2024.

[67]王瑞宁,周瑞红,赵子雅,等.北极狐Wnt3a基因CDS区克隆及生物信息学分析[J].畜牧与兽医,2020, 52(10):7-12.

[68]王瑞宁,赵子雅,冯硕,等.赤狐DCT基因生物信息学分析[J].黑龙江畜牧兽医,2019(23):127-130, 173.

[69]鲍加荣.赤狐和银黑狐毛色差异分析、色素基因克隆及TYRP1功能初步研究[D].北京:中国农业科学院,2015.

[70]刘华云,张磊,徐桂利,等.银黑狐MC1R基因核心启动子区的鉴定[J].中国畜牧兽医,2022, 49(7):2442-2450.

[71]刘华云,李寒妹,李想,等.北极蓝狐和北极白狐PMEL基因不同组织差异的表达[J].河北科技师范学院学报,2022, 36(2):50-53.

[72]郑晓宁,王瑞宁,王亚琪,等.北极狐TYRP1基因启动子活性及转录调控区域分析[J].中国兽医学报,2018, 38(12):2366-2373.

[73]郭敏,赵子雅,王瑞宁,等.北极狐β-防御素103基因(CBD103)启动子活性及转录调控元件分析[J].生物工程学报,2019, 35(8):1469-1477.

[74]Skorczyk A, Flisikowski K, Switonski M. A comparative analysis of MC4R gene sequence, polymorphism, and chromosomal localization in Chinese raccoon dog and Arctic fox[J].DNA and Cell Biology, 2012, 31(5):732-738.

[75]Yamamoto S, Murase M, Miyazaki M, et al. A mutant gene for albino body color is widespread in natural populations of tanuki(Japanese raccoon dog)[J]. Genes&Genetic Systems,2021, 96(1):33-39.

[76]霍自双.红眼白水貂主要生产性状相关基因的表达及相关性分析[D].哈尔滨:东北农业大学,2018.

[77]霍自双,刘宗岳,岳志刚,等.红眼白水貂FSHβ和NCOA1基因多态性及其与繁殖性状的相关分析[J].中国畜牧兽医,2018, 45(2):429-438.

[78]杨童奥,杨雅涵,刘华淼,等.银黑狐、蓝狐及其杂交后代准备配种期和配种期MEIG1基因的表达规律[J].吉林农业大学学报,2019, 41(5):621-624.

[79]黄贺.北极狐ESR和FSHR基因多态性、表达及其与产仔关系的研究[D].哈尔滨:东北林业大学,2013.

[80]Sugiura N, Ochiai K, Yamamoto T, et al. Examining multiple paternity in the raccoon dog(Nyctereutes procyonoides)in Japan using microsatellite analysis[J]. The Journal of Veterinary Medical Science, 2020, 82(4):479-482.

[81]李虎,周建颖,石宏宇,等.乌苏里貉PRLR和RBP4基因多态性检测及其与繁殖性能的关联分析[J].经济动物学报,2026, 30(2):106-111.

[82]周瑞红,彭永东,李祥龙.赤狐ESR1基因启动子的克隆及生物信息学分析[J].河北科技师范学院学报,2021,35(1):1-6.

[83]李玉梅,赵云,孙博兴,等.水貂EGF基因SNPS与皮张长度的相关性试验[J].中国兽医学报,2011, 31(6):921-925.

[84]刘琳玲,宋姗姗,丛波,等.水貂阿片黑皮质素前体POMC基因SNPs检测及其与生长性状的关联分析[J].特产研究,2019, 41(4):41-46.

[85]Grzes M, Nowacka-Woszuk J, Szczerbal I, et al. A comparison of coding sequence and cytogenetic localization of the myostatin gene in the dog, red fox, Arctic fox and Chinese raccoon dog[J]. Cytogenetic and Genome Research, 2009,126(1/2):173-179.

[86]Skorczyk A, Stachowiak M, Szczerbal I, et al. Polymorphism and chromosomal location of the MC4R(melanocortin-4 receptor)gene in the dog and red fox[J]. Gene, 2007, 392(1/2):247-252.

[87]Niiranen L, MäkeläK A, Mutt S J, et al. Role of brown and beige adipose tissues in seasonal adaptation in the raccoon dog(Nyctereutes procyonoides)[J]. International Journal of Molecular Sciences, 2021, 22(17):9623.

[88]Cai Z X, Petersen B, Sahana G, et al. The first draft reference genome of the American mink(Neovison vison)[J]. Scientific Reports, 2017, 7:14564.

[89]Karimi K, Do D N, Wang J, et al. A chromosome-level genome assembly reveals genomic characteristics of the American mink(Neogale vison)[J]. Communications Biology, 2022,5:1381.

[90]Cai Z X, Villumsen T M, Asp T, et al. SNP markers associated with body size and pelt length in American mink(Neovison vison)[J]. BMC Genetics, 2018, 19(1):103.

[91]Karimi K, Farid A H, Myles S, et al. Detection of selection signatures for response to Aleutian mink disease virus infection in American mink[J]. Scientific Reports, 2021, 11:2944.

[92]Davoudi P, Do D N, Rathgeber B, et al. Genome-wide detection of copy number variation in American mink using wholegenome sequencing[J]. BMC Genomics, 2022, 23(1):649.

[93]Lan T M, Li H M, Yang S C, et al. The chromosome-scale genome of the raccoon dog:Insights into its evolutionary characteristics[J]. iScience, 2022, 25(10):105117.

[94]Zhang H H, Chen L. The complete mitochondrial genome of the raccoon dog[J]. Mitochondrial DNA, 2010, 21(3/4):59-61.

[95]Kim H R, Cho J Y, Park Y C. Intraspecific comparison of complete mitogenome sequences from two Asian raccoon dogs(Canidae:Nyctereutes procyonoides)[J]. Mitochondrial DNA, 2015, 26(6):827-828.

[96]Slaska B, Grzybowska-Szatkowska L. Analysis of the mitochondrial haplogroups of farm and wild-living raccoon dogs in Poland[J]. Mitochondrial DNA, 2011, 22(4):105-110.

[97]刘华云.北极白狐毛色季节性变化及差异表达基因的筛选与验证[D].秦皇岛:河北科技师范学院,2022.

[98]周瑞红.蓝狐皮肤组织转录组分析及毛色形成初步研究[D].秦皇岛:河北科技师范学院,2021.

[99]姜恩泽.乌苏里貉(Nyctereutes procyonoides)黑色素沉积及毛色基因筛选的研究[D].哈尔滨:东北农业大学,2020.

[100]杜站宇.白貉、乌苏里貉皮毛及皮肤中黑色素沉积的研究[D].长春:吉林农业大学,2017.

基本信息:

DOI:10.13326/j.jea.2026.2091

中图分类号:S865.2

引用信息:

[1]张新玉,石宏宇,张铁涛,等.毛皮动物育种技术研究进展[J].经济动物学报,2026,30(02):87-95+157.DOI:10.13326/j.jea.2026.2091.

基金信息:

中国农业科学院科技创新工程项目(CAAS-ASTIP-ISAPS-2025)

发布时间:

2025-05-20

出版时间:

2025-05-20

网络发布时间:

2025-05-20

检 索 高级检索