吴健1,2,3,4,5,6
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拷贝数变异（CNV）是一种重要的遗传变异形式。胰岛素样生长因子1受体（IGF1R）与骨骼发育和肌肉细胞增殖等相关，且IGF1R CNV与西北黄牛生长性能相关，然而其CNV与中国东北地区品种牛生长性状的研究尚未有相关报道。因此，本试验旨在研究IGF1R CNV与中国东北地区品种牛生长性状的相关性。采用qRT-PCR方法检测IGF1R CNV的分布及其mRNA的表达水平，并将CNV与生长性状进行关联分析。结果发现，IGF1R在各个品种牛中均存在不同类型的CNV，且IGF1R CNV与草原红牛（CYH）体重、体高、十字部高、体斜长、胸围、尻宽、腰脚宽、腹围和眼肌面积，延边牛（YB）背膘厚以及延黄牛（YH）体重、体高和十字部高显著相关。综上所述，IGF1R CNV与中国东北地区品种牛生长性状显著相关，可作为牛育种的分子标记。
Abstract：Copy number variation (CNV) is an important form of genetic variation. Insulin-like growth factor 1 receptor (IGF1R) is associated with bone development and muscle cell proliferation， and IGF1R CNV is associated with growth performance in northwestern yellow cattle. However， there are no reports on the relationship between its CNV and growth traits of cattle breeds in Northeast China. Therefore， this experiment aims to investigate the correlation between IGF1R CNV and growth traits of cattle breeds in Northeast China. The qRT-PCR method was used to detect the distribution and mRNA expression level of IGF1R CNV， and correlation analysis was performed between CNV and growth traits. The results showed that IGF1R had different types of CNVs in different breeds of cattle， and IGF1R CNVs were significantly correlated with body weight， body height， hip height， body slanting length， chest girth， abdominal girth， hip width， rump width and eye muscle area of Grassland Red cattle (CYH)， backfat thickness of Yanbian cattle (YB)， and body weight， body height and hip height of Yan Yellow cattle (YH). In conclusion， IGF1R CNV is significantly correlated with growth traits of cattle breeds in Northeast China and can serve as a molecular marker for cattle breeding.
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基本信息:
中图分类号:S823
引用信息:
[1]刘基伟,罗晓彤,李轩宇,等.IGF1R基因拷贝数变异与不同品种牛生长性状的关联[J].经济动物学报().
基金信息:
国家肉牛牦牛产业技术体系(CARS-37); 雪花牛肉提质增量生产技术集成与示范(2024); 吉林省肉牛专项（YDZJ202203CGZH044）; 国家肉牛牦牛产业技术体系（CARA-37）; 肉牛遗传资源开发利用及科技提质增效（202402）; 吉林省农业科学院创新工程项目（CXGC2022RCG007）
2025-03-10
2025-03-10
2025-03-10