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肠道疾病是制约畜禽、水产及伴侣动物健康养殖的关键因素。抗生素的长期滥用已引发严重的耐药性、药物残留及生态失衡问题，亟需绿色安全的替代策略。微生态制剂（包括益生菌、益生元及合生元）通过调节肠道微生态平衡、增强肠道屏障功能、调节免疫应答及竞争性抑制病原菌等机制，在预防和治疗多种动物肠道疾病中展现出巨大潜力。本文系统综述了微生态制剂对肠道疾病防治的作用机制，重点阐述了其在禽类、猪、犬猫、水产动物、毛皮动物及反刍动物等不同种属动物肠道疾病防治中的研究进展与应用效果，以期为微生态制剂在畜牧生产中的科学应用提供理论参考和实践指导。
Abstract：Intestinal diseases are key factors restricting the healthy breeding of livestock， poultry， aquatic animals and companion animals. The long-term abuse of antibiotics has led to serious problems such as drug resistance， drug residues and ecological imbalance， and there is an urgent need for green and safe alternative strategies. Microecological preparations (including probiotics， prebiotics and synbiotics) have shown great potential in the prevention and treatment of various animal intestinal diseases through mechanisms such as regulating intestinal microecological balance， enhancing intestinal barrier function， regulating immune response and competitively inhibiting pathogenic bacteria. This article systematically reviews the mechanism of action of microecological preparations in the prevention and treatment of intestinal diseases， and focuses on the research progress and application effects in different species of animals such as poultry， pigs， dogs and cats， aquatic animals， fur animals and ruminants， with the aim of providing theoretical references and practical guidance for the scientific application of microecological preparations in livestock production.
[1]韩雪冰，元香南，方俊，等.乳酸菌维持动物肠道健康的研究进展[J].中国科学:生命科学，2023，53(04):464-479.
[2]李娟，汪仁军.益生菌对动物肠道微生物的影响及其调控机制研究[J].畜牧业环境，2023，(15):15-16.
[3]张达荣.肠道疾病中微生态制剂的应用[J].上海预防医学杂志，2004，(04):175-177.
[4]Taká?ová M， Bomba A， Tóthová C， et al. Any future for faecal microbiota transplantation as a novel strategy for gut microbiota modulation in human and veterinary medicine[J]. Life， 2022， 12(5): 723.
[5]Saettone V， Biasato I， Radice E， et al. State-of-the-Art of the nutritional alternatives to the use of antibiotics in humans and monogastric animals[J]. Animals， 2020， 10(12): 2199.
[6]Gibson G R， Roberfroid M B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics[J]. The Journal of Nutrition， 1995， 125(6): 1401-1412.
[7]Plaza-Díaz J， Ruiz-Ojeda F J， Vilchez-Padial L M， et al. Evidence of the anti-inflammatory effects of probiotics and synbiotics in intestinal chronic diseases[J]. Nutrients， 2017， 9(6): 555.
[8]池永宽，刘旭光，陈浒，等.微生态制剂的作用机制及其在动物生产中的应用[J].微生物学杂志，2022，42(03):100-109.
[9]张洪伟，谭美姝，冯曼，等.益生菌调控动物肠道功能的机制及应用研究进展[J].中国动物传染病学报，2026，1-11.
[10]O'Hara AM， Shanahan F. Mechanisms of action of probiotics in intestinal diseases[J]. The Scientific World Journal， 2007， 7: 31-46.
[11]Monteagudo-Mera， Robert A R， Gibson G R， et al. Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health[J]. Applied Microbiology and Biotechnology， 2019， 103(16): 6463-6472.
[12]Liu J J， Yan Q L， Li S H， et al. Integrative metagenomic and metabolomic analyses reveal the potential of gut microbiota to exacerbate acute pancreatitis[J]. NPJ Biofilms Microbiomes， 2024， 10(1): 29.
[13]Barasarathi， Perveen， Khan， et al. Targeting agrobacterium tumefaciens: a computational study on quorum sensing inhibition[J]. Journal of Basic Microbiology， 2025， 65(7): e70041.
[14]Matar A， Damianos J A， Jencks K J， et al. Intestinal barrier impairment， preservation and repair: an update[J]. Nutrients， 2024， 16(20): 3494.
[15]Maldonado Galdeano C， Cazorla S I， Lemme Dumit J M， et al. Beneficial effects of probiotic consumption on the immune system[J]. Annals of Nutrition and Metabolism， 2019， 74(2): 115-124.
[16]Alakomi H， Skytt? E， Saarela M， et al. Lactic acid permeabilizes gram-negative bacteria by disrupting the outer membrane[J]. Applied and Environmental Microbiology， 2000. 66(5): 2001-2005.
[17]Cotter P， Hill C， Ross R， et al. Bacteriocins: developing innate immunity for food[J]. Nature Reviews Microbiology， 2013， 11(10): 665-675.
[18]Morrison， Douglas J， Tom P. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism[J]. Gut Microbes， 2016， 7(3): 189-200.
[19]Al-Habsi N， Al-Khalili M， Haque S A， et al. Health benefits of prebiotics， probiotics， synbiotics， and postbiotics[J]. Nutrients， 2024， 16(22): 3955.
[20]Emami N K， Dalloul R A. Centennial Review: Recent developments in host-pathogen interactions during necrotic enteritis in poultry[J]. Poultry Science， 2021， 100(9): 101330.
[21]Ningsih N， Respati A N， Astuti D， et al. Efficacy of bacillus subtilis to replace in-feed antibiotics of broiler chickens under necrotic enteritis-challenged experiments: A systematic review and meta-analysis[J]. Poultry Science， 2023， 102(10): 102923.
[22]Clavijo V， Vives Flórez M J. The gastrointestinal microbiome and its association with the control of pathogens in broiler chicken production: A review[J]. Poultry Science， 2018， 97(3): 1006-1021.
[23]Vandeplas S，Dubois Dauphin R， Beckers Y， et al. Salmonella in chicken: current and developing strategies to reduce contamination at farm level[J]. Journal of Food Protection， 2010， 73(4): 774-785.
[24]Patterson J A， Burkholder K M. Application of prebiotics and probiotics in poultry production[J]. Poultry Science， 2003， 82(4): 627-631.
[25]Spring P， Wenk C， Dawson K A， et al. The effect of dietary mannanoligosaccharides on cecal parameters and the concentrations of enteric bacteria in the ceca of Salmonella-challenged broiler chicks[J]. Poultry Science， 2000， 79(2): 205-211.
[26]Pan D， Yu Z T. Intestinal microbiome of poultry and its interaction with host and diet[J].Gut Microbes， 2014， 5(1): 108-119.
[27]Deryabin D， Lazebnik C， Vlasenko L， et al. Broiler chicken cecal microbiome and poultry farming productivity: A meta-analysis[J]. Microorganisms. 2024， 12(4): 747.
[28]赵祥伟，苗纪昌，刘宝元.禽类肠道疾病益生菌防治应用探究[J].中国畜禽种业，2020，16(08):188.
[29]胡振梅，赵录波，孙玉红.益生菌对家禽肠道健康影响的研究进展[J].中国动物保健，2024，26(05):111-112.
[30]赵永旺，管远红，陈光明，等.益生菌防治家禽肠道疾病研究进展[J].畜牧兽医科技信息，2020，(12):17-18.
[31]楚玉婷，朱阳华，谢长清，等.枯草芽孢杆菌复合微生物制剂对鸡坏死性肠炎的预防效果[J].华中农业大学学报，2024，43(03):275-281.
[32]Rossi R， Mainardi E. Prebiotics and probiotics supplementation in pigs as a model for human gut health and disease[J]. Biomolecules， 2025， 15(5): 665.
[33]Jiang Z P， Yang M X， Su W F， et al. Probiotics in piglet from gut health to pathogen defense mechanisms[J]. Frontiers in Immunology， 2024， 15(4): 1468873.
[34]Zeng Y， Xiong K N， Zhong J F， et al. Bacillus spp. as potential probiotics promoting piglet growth by improving intestinal health[J]. Frontiers in Veterinary Science， 2024， 11: 1429233.
[35]Liu Y， Dong B， Yang Y L， et al. Intestinal microbiota dynamics in piglets: the interplay with swine enteric coronavirus infections and implications for disease control[J]. anim microbiome， 2025， 7(1): 107.
[36]Wang S， Yao B， Gao H，et al. Combined supplementation of Lactobacillus fermentum and Pediococcus acidilactici promoted growth performance， alleviated inflammation， and modulated intestinal microbiota in weaned pigs[J]. BMC Vet Res. 2019， 15(1): 239.
[37]史洪岩.益生菌在猪流行性腹泻防治中的应用[J].畜牧兽医科技信息，2022，(11): 196-197.
[38]Upadhaya S D， Kim I H. Maintenance of gut microbiome stability for optimum intestinal health in pigs-a review[J]. Animal Sci Biotechnol， 2022， 13(1): 140.
[39]Zhang Y， Zhang Y， Liu F， et al. Mechanisms and applications of probiotics in prevention and treatment of swine diseases[J]. Porcine Health Manag， 2023， 9(1): 5.
[40]Jergens A E， Simpson K W. Inflammatory bowel disease in veterinary medicine[J]. Front. Biosci， 2012， 4(4): 1404-1419.
[41]Honneffer J B， Minamoto Y， Suchodolski J S， et al. Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs[J]. World J Gastroenterol， 2014， 20(44): 16489-16497.
[42]Li C， Niu Z， Zou M， et al. Probiotics， prebiotics， and synbiotics regulate the intestinal microbiota differentially and restore the relative abundance of specific gut microorganisms[J]. J Dairy Sci， 2020， 103(7): 5816-5829.
[43]Orel R， Kamhi Trop T. Intestinal microbiota， probiotics and prebiotics in inflammatory bowel disease[J]. World J Gastroenterol， 2014， 20(33): 11505-11524.
[44]Han T， Zhang Y， Zheng G， et al. From pathogenic mechanisms to therapeutic perspectives: a review of gut microbiota and intestinal mucosal immunity in inflammatory bowel disease[J]. Front Immunol. 2025， 16: 1704651.
[45]Kelley R L， Minikhiem D， Kiely B， et al. Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea[J]. Vet Ther， 2009， 10(3): 121-3010.
[46]瞿彬，徐文昌，宋雪琳，等.益生菌制剂在水产养殖中的应用[J].饲料工业，2023，44(16):62-70.
[47]Zhang Y， Liang X F， He S， et al. Dietary supplementation ofexogenous probiotics affects growth performance and gut healthby regulating gut microbiota in Chinese Perch (Siniperca chuatsi)[J]. Aquaculture， 2022， 547: 737405.
[48]孔祎頔，田佳鑫，陈秀梅，等.水产动物益生菌及其对肠道菌群影响的研究进展[J].中国畜牧杂志，2019，55(01):29-33.
[49]刘凤华，牛停举，赵德辉，等.益生菌对动物肠道健康的作用机制及其在毛皮动物生产中的应用[J].饲料工业，2025，46(03):9-13.
[50]庄金秋，梅建国，沈志强.水貂细小病毒性肠炎实验室诊断方法研究进展[J].经济动物学报，2011，15(04):225-229.
[51]李光玉，赵梦迪，张媛媛，等.益生菌在毛皮动物生产中的应用[J].经济动物学报，2025，29(04):263-271+260.
[52]Pinloche E， McEwan N， Marden J P， et al. The Effects of a Probiotic Yeast on the Bacterial Diversity and Population Structure in the Rumen of Cattle[J]. PLoS One， 2013， 8(7): e67824.
[53]Callaway E S， Martin S A. Effects of a Saccharomyces cerevisiae culture on ruminal bacteria that utilize lactate and digest cellulose[J]. 1997， 80(9)， 2035-44.
[54]Du Y， Gao Y， Hu M， et al. Colonization and development of the gut microbiome in calves[J].J Animal Sci Biotechnol， 2023， 14(1): 46.
[55]张思卓.益生菌制剂防治犊牦牛腹泻的作用机理[J].当代畜牧，2021，(12):20-22.
[56]唐俊，贺荔，王彭辉，等.肠道微生物在反刍动物健康生产中的作用研究进展[J].中国畜牧兽医，2024，51(04):1466-1479.
[57]余小红，刘晗璐，赵德辉，等.反刍动物益生菌制剂的研究进展[J].饲料工业，2024，45(17):18-23.
[58]郁冯艳，付佳伟，从光雷，等.微生态制剂在反刍动物生产中的研究与应用[J].广东饲料，2024，33(03):34-37.
[59]刘雨晴，潘金龙，陈伟，等.益生菌应用于反刍动物生产的前景及存在问题[J].北方牧业，2024，(23):13.
[60]李俊峰，廖凯威，李彪，等.益生菌在反刍动物中的应用[J].中国饲料，2024，(17):197-202.
基本信息:
中图分类号:S856.4
引用信息:
[1]丁宁,杨树宝,马馨.微生态制剂在动物肠道疾病防治中的应用研究进展[J].经济动物学报().
基金信息:
吉林省科技发展计划项目（YDZJ202201ZYTS176）
2026-05-22
2026-05-22
2026-05-22