| 81 | 0 | 39 |
| 下载次数 | 被引频次 | 阅读次数 |
肠道微生物与病毒感染的相互作用机制已成为当前感染性疾病研究的重要领域。随着肠道菌群在维持机体健康中的作用日益明确，其在病毒感染过程中的调控功能逐渐受到关注。外科手术患者由于肠道微生态易受手术应激、麻醉及抗生素干预等因素影响，其病毒感染特征与普通人群存在显著差异。本文围绕肠道细菌对病毒感染的促进作用，系统综述了直接与间接两类作用机制。直接机制包括细菌表面成分增强病毒颗粒稳定性及其与宿主细胞受体的结合效率；间接机制涉及菌群对干扰素信号通路、抗体产生及免疫耐受环境的调节作用。通过对现有研究证据的综合分析，本文旨在深化对病毒-细菌-宿主三方相互作用的理解，并为相关感染疾病的防治策略提供理论参考。
Abstract：Interactions between the gut microbiota and viral infections have become a major focus in contemporary infectious disease research. As the role of the intestinal microbiota in maintaining host health has become increasingly clear, its regulatory functions in the process of viral infection have gradually attracted attention. In surgical patients, the intestinal microecological balance is susceptible to surgical stress, anesthesia, and antibiotic exposure, resulting in viral infection profiles that are significantly different from those of the general population. This article focuses on the promotive effects of intestinal bacteria on viral infections and systematically summarizes direct and indirect mechanisms of interaction. The direct mechanisms include the surface components of bacteria enhancing the stability of viral particles and increasing viral binding efficiency to host cell receptors; indirect mechanisms involve the regulatory effects of the microbiota on interferon signaling pathways, antibody production, and the establishment of an immune-tolerant environment. Through a comprehensive analysis of the existing research evidence, this review aims to deepen the understanding of the interaction among viruses, bacteria, and hosts, and to provide a theoretical basis for the prevention and treatment strategies of related infectious diseases.
[1]段伟，李冀琛，李慧洁，等.肠道病毒D68型VP1-N90K突变增强其在乳鼠感染致病力研究[J].病毒学报，2025, 41(6):1710-1722. DOI:10. 13242/j. cnki.bingduxuebao. 250320.
[2]Hamidi M, Ong KC, Tan SH, et al. An intracerebrallyinfected mouse model of enterovirus A71 demonstrates restricted inter-neuronal spread within the brain parenchyma despite strong SCARB2 expression[J].Neuropathol Appl Neurobiol, 2025, 51(4):e70031.DOI:10. 1111/nan. 70031.
[3]Liu Y, Chen J, Du N, et al. Mechanism research of Punicalagin in treating representative strains of enterovirus A and B types based on systems pharmacology and experimental validation[J]. Virol J,2025, 22(1):229. DOI:10. 1186/s12985-025-02845-0.
[4]Chang HY, Ong KC, Jasni K, et al. Viral interference during coinfection and sequential infection of enterovirus A71 and coxsackievirus A16[J]. Virology, 2025, 610:110610. DOI:10. 1016/j. virol. 2025. 110610.
[5]Yang T, He G, Chen L, et al. Pexophagy triggered by enterovirus 71 modulates the production of proinflammatory cytokines through cholesterol accumulation in lysosomes[J]. J Med Virol, 2025, 97(9):e70578.DOI:10. 1002/jmv. 70578.
[6]Du N, Chen J, Liu Y. The application and discovery of animal models in enterovirus research[J]. Arch Virol,2025, 170(8):175. DOI:10. 1007/s00705-025-06367-6.
[7]Zou Z, Liu J, Fu L, et al. Animal models for enterovirus 71:Mechanisms, immunity, and applications[J]. Hum Vaccin Immunother, 2025, 21(1):2523109. DOI:10. 1080/21645515. 2025. 2523109.
[8]Yu F, Xiong D, Zhong Y, et al. Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice[J]. J Virol, 2025, 99(10):e0120725. DOI:10. 1128/jvi. 01207-25.
[9]Xiao M, Han Z, Ma X, et al. Global evolution and transmission dynamics of enterovirus D68[J]. J Med Virol, 2025, 97(7):e70497. DOI:10. 1002/jmv. 70497.
[10]Li K, Rudy MJ, Hu Y, et al. A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis[J]. Nat Commun, 2025, 16(1):5987. DOI:10. 1038/s41467-025-61083-8.
[11]Mustafa S, Abd-Aziz N, Yusoff K, et al. Soluble recombinant enterovirus 71 VP1 fused to truncated Newcastle disease virus nucleoprotein elicits immune responses in mice[J]. Braz J Microbiol, 2025, 56(4):2743-2755. DOI:10. 1007/s42770-025-01784-w.
[12]Chen K, Hong D, Zeng L, et al. Construction of enterovirus G expressing reporter genes for antiviral drug screening assays[J]. BMC Vet Res, 2025, 21(1):515. DOI:10. 1186/s12917-025-04960-0.
[13]Ng TFF, Nix WA, Rogers SL, et al. Type-specific EV-D68 real-time RT-PCR assay for the detection of all extant enterovirus D68 strains[J]. J Clin Microbiol,2025, 63(9):e01492-e01422. DOI:10. 1128/jcm. 01492-22.
[14]肖金波，张勇.肠道病毒病的防控现状、核心难题及创新方向[J].病毒学报，2025,41(6):1691-1701. DOI:10. 13242/j. cnki. bingduxuebao. 250287.
[15]Xu J, Zhan X, Wang F, et al. Discovery of proteinaceous attachment factors for GII. 4 norovirus from the diarrheal sample of a norovirus-infected patient[J]. Food Environ Virol, 2025, 17(4):50. DOI:10. 1007/s12560-025-09664-0.
[16]Xie L, Wu Y, Huang Q, et al. Correlation between the mutation rates for ampC derepression and species or ampC genotypes in Enterobacter cloacae complex[J].BMC Microbiol, 2025, 25(1):581. DOI:10. 1186/s12866-025-04310-y.
[17]梁丹，项利娟，周军.免疫介导的胃肠道疾病中病毒作用机制的研究新进展[J].病毒学报，2025, 41(4):1261-1268.DOI:10. 13242/j.cnki.bingduxuebao. 250148.
[18]Johnson R, Brola A, Wycoff C, et al. Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways[J]. Biomol Biomed, 2025, 26(3):424-432. DOI:10. 17305/bb. 2025. 12852.
[19]Bhowmick S, Mistri TK, Okla MK, et al.Identification of potential 3CLpro inhibitors-modulators for human norovirus infections through an advanced virtual screening approach[J]. J Biomol Struct Dyn,2025:1-17. DOI:10. 1080/07391102. 2025. 2502672.
[20]Schipper JG, Aloise C, Sutter SO, et al. The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses[J]. PLoS Pathog, 2025, 21(8):e1013443. DOI:10. 1371/journal. ppat. 1013443.
[21]Bhuinya A, Dass D, Banerjee A, Mukherjee A. A tale of antiviral counterattacks in rotavirus infection[J].Microbiol Res,2022,260:127046. DOI:10. 1016/j.micres. 2022. 127046..
[22]Roth AN, Helm EW, Mirabelli C, et al. Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice[J]. Nat Commun, 2020, 11:2968.DOI:10. 1038/s41467-020-16798-1.
[23]Bifani AM, Tee HK, Antanasijevic A, et al.Enterovirus A71 priorities, challenges, and future opportunities in humoral immunity and vaccine development[J]. NPJ Vaccines, 2025, 10(1):194.DOI:10. 1038/s41541-025-01184-z.
[24]Ga YJ, Go YY, Yeh JY. Small interfering RNAs targeting VP4, VP3, 2B, or 3A coding regions of enterovirus A71 inhibit viral replication in vitro[J].Biomedicines, 2025, 13(7):1760. DOI:10. 3390/biomedicines13071760.
[25]麻雯熠，孙萍萍，王佳慧，等.肠道病毒A71型亚单位蛋白对RD细胞自噬活化的影响[J].病毒学报，2023,39(3):720-728. DOI:10. 13242/j. cnki.bingduxuebao. 004323.
[26]Li ZH, Zhang ZX, Zhu P, et al. Colorimetric reverse transcription loop-mediated isothermal amplification assay for visual, sensitive, and specific detection of enterovirus G[J]. BMC Vet Res, 2025, 21(1):529.DOI:10. 1186/s12917-025-04970-y.
[27]Huang X, Wang S, Huang Y, et al. ARRDC3promotes lysosome-mediated YAP degradation to inhibit enterovirus replication[J]. Virol Sin, 2025, 40(4):658-668. DOI:10. 1016/j. virs. 2025. 07. 009.
[28]张哲，王涛，王志云.肠道病毒与细胞凋亡的关系[J].病毒学报，2023, 39(6):1731-1739. DOI:10. 13242/j. cnki. bingduxuebao. 004502.
基本信息:
中图分类号:R512.5;R574
引用信息:
[1]唐人敬,李国强,赵丽君.肠道病毒感染与细菌的作用机制研究现状[J].病毒学报().
2026-02-24
2026-02-24
2026-02-24