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安第斯病毒研究进展
基金项目(Foundation): 国家自然科学基金地区科学基金(项目号:32060810),题目:PGAM5调控cGAS-STING信号通路抗CPV感染的分子机制;国家自然科学基金地区科学基金(项目号:31960710),题目:基于宏基因组学的陕北地区羔羊腹泻主要病原的筛选及鉴定; 陕西省科技厅中央引导地方科技发展资金项目(项目号:2025ZY-XCZXJX-12),题目:陕北白绒山羊羊肉高效生产与肉质评价技术集成示范; 陕西省创新能力支撑计划项目(项目号:2021PT-017),题目:陕北白绒山羊全产业链综合性检验检测平台
邮箱(Email): zhaijunjun1980@163.com;zhang-yan1825@163.com;
DOI:
发布时间: 2026-01-27
出版时间: 2026-01-27
网络发布时间: 2026-01-27
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摘要:

安第斯病毒(Andes virus, ANDV)是一种具有高度致病性和人际间传播能力的单股负链RNA病毒,人感染ANDV后可导致汉坦病毒肺综合征(HPS),病死率极高。目前,尚无有效疫苗或特异性抗病毒药物可用于ANDV的预防和治疗,使其成为重要的潜在公共卫生威胁。尽管尚未在我国发现本地感染病例,但在全球人员流动加剧背景下,ANDV存在输入性风险。本文对ANDV的病原生物学、流行病学、临床症状与病理变化、预防与治疗等方面的最新研究进展进行系统介绍,为进一步设计有效疫苗、开发治疗药物奠定基础。

Abstract:

Andes virus(ANDV) is a highly pathogenic and human-to-human transmissible single-stranded negative-sense RNA virus. Human infection with ANDV can lead to Hantavirus Pulmonary Syndrome(HPS) with a high mortality. At present, there are no effective vaccines or specific antiviral drugs available for the prevention and treatment of ANDV, which makes ANDV infection an increasingly serious public health problem. This review introduces the latest research progress on the pathogenic biology, viral replication, epidemiology, clinical symptoms and pathological changes, prevention and treatment of ANDV, laying the foundation for further design of effective vaccines and development of therapeutic drugs.

参考文献

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基本信息:

中图分类号:R373

引用信息:

[1]贺安文,景志忠,何小兵,等.安第斯病毒研究进展[J].病毒学报().

基金信息:

国家自然科学基金地区科学基金(项目号:32060810),题目:PGAM5调控cGAS-STING信号通路抗CPV感染的分子机制;国家自然科学基金地区科学基金(项目号:31960710),题目:基于宏基因组学的陕北地区羔羊腹泻主要病原的筛选及鉴定; 陕西省科技厅中央引导地方科技发展资金项目(项目号:2025ZY-XCZXJX-12),题目:陕北白绒山羊羊肉高效生产与肉质评价技术集成示范; 陕西省创新能力支撑计划项目(项目号:2021PT-017),题目:陕北白绒山羊全产业链综合性检验检测平台

发布时间:

2026-01-27

出版时间:

2026-01-27

网络发布时间:

2026-01-27

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