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基因2型鹅星状病毒（Goose astrovirus genotype 2, GAstV-2）引起的雏鹅痛风，是一种以雏鹅内脏器官及关节尿酸盐沉积为典型病理特征的传染性疾病。该病主要侵袭3周龄以内雏鹅，发病率和死亡率较高，耐过鹅生长迟缓、免疫力低下，且易继发细菌感染。近年来，该病在我国主要养鹅地区广泛流行，给养鹅业造成了严重的经济损失。GAstV-2已被证实可感染樱桃谷鸭、番鸭、鸡等，存在跨种传播风险，对家禽养殖业构成了更广泛的威胁。由于该病的致病机制尚未完全阐明，加之GAstV-2毒株遗传变异频繁、临床混合感染现象普遍，目前尚无商品化疫苗。基于此，本文系统梳理GAstV-2引起的雏鹅痛风在病原学、流行病学、致病机制、诊断技术及防控策略等方面的最新研究成果，旨在为该病的监测预警、致病机制深入解析及防控策略科学制定提供理论支撑。
Abstract：Gosling gout caused by goose astrovirus genotype 2(GAstV-2) is an infectious disease characterized by urate deposition in the visceral organs and joints of goslings. The disease mainly affects goslings younger than 3 weeks of age and is associated with high morbidity and mortality. Surviving goslings often exhibit growth retardation, immunosuppression, and increased susceptibility to secondary bacterial infections. In recent years, the disease has become widely prevalent in major goose-producing regions of China, causing substantial economic losses to the goose industry. GAstV-2 has also been confirmed to infect Cherry Valley ducks, Muscovy ducks, and chickens, indicating a potential risk of cross-species transmission and posing a broader threat to the poultry industry. Owing to the incomplete understanding of its pathogenic mechanisms, together with the frequent genetic variation among GAstV-2 strains and the common occurrence of mixed infections in clinical settings, no commercial vaccine is currently available. Therefore, this review systematically summarizes recent advances in the etiology, epidemiology, pathogenic mechanisms, diagnostic techniques, and prevention and control strategies of GAstV-2-associated gosling gout, with the aim of providing a theoretical basis for disease surveillance and early warning, further elucidation of pathogenic mechanisms, and the scientific development of prevention and control strategies.
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基本信息:
中图分类号:S858.33
引用信息:
[1]孙凯运,邱杨,张雪征,等.基因2型鹅星状病毒相关雏鹅痛风的研究进展[J].病毒学报().
2026-05-29
2026-05-29
2026-05-29